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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Cornelia de Lange syndrome


Other Names for this Disease
  • Brachmann de Lange syndrome
  • Brachmann-de Lange syndrome
  • CDLS
  • De Lange syndrome
  • Typus degenerativus amstelodamensis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might Cornelia de Lange syndrome be treated?

Because Cornelia de Lange syndrome (CdLS) affects many different systems of the body, medical management is often provided by a team of doctors and other healthcare professionals. Treatment for this condition varies based on the signs and symptoms present in each person. For example, many people affected by CdLS have poor growth after birth and may require supplemental formulas and/or gastrostomy tube placement to meet nutritional needs. Ongoing physical, occupational, and speech therapies are often recommended to optimize developmental potential. Surgery may be necessary to treat skeletal abnormalities, gastrointestinal problems, congenital heart defects and other health problems. Medications may be prescribed to prevent or control seizures.[1][2]

The CdLS foundation's Web site offers more specific information about the treatment and management of CdLS. Please click on the link to access this resource.
Last updated: 7/29/2015

References
  1. Matthew A Deardorff, MD, PhD, Dinah M Clark, MS, and Ian D Krantz, MD. Cornelia de Lange Syndrome. GeneReviews. October 2011; http://www.ncbi.nlm.nih.gov/books/NBK1104/#cdls.Diagnosis.
  2. Mustafa Tekin, MD. Cornelia De Lange Syndrome. Medscape Reference. April 2015; http://emedicine.medscape.com/article/942792-overview.


GARD Video Tutorial

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Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Cornelia de Lange syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Brachmann de Lange syndrome
  • Brachmann-de Lange syndrome
  • CDLS
  • De Lange syndrome
  • Typus degenerativus amstelodamensis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.