Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Periventricular leukomalacia


Other Names for this Disease
  • PVL
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Periventricular leukomalacia (PVL) is a brain injury disorder characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the area around the ventricles of the brain, which results in the death of brain tissue. Although babies with PVL generally have no apparent signs or symptoms of the disorder at delivery, they are at risk for motor disorders, cerebral palsy, delayed mental development, coordination problems, and vision and hearing impairments.[1]There is no cure for PVL. Treatment is generally supportive. Prognosis is dependent on the extent of damage to the ventricles.[2]
Last updated: 3/22/2016

References

  1. NINDS Periventricular Leukomalacia Information Page. National Institute of Neurological Disorders and Stroke (NINDS). March 15, 2016; http://www.ninds.nih.gov/disorders/periventricular_leukomalacia/periventricular_leukomalacia.htm.
  2. Terence Zach. Pediatric Periventricular Leukomalacia. Medscape. January 16, 2015; http://emedicine.medscape.com/article/975728-overview.
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Your Questions Answered
Your Questions Answered
View questions about this condition answered by GARD Information Specialists. You can also submit a new question.

Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Periventricular leukomalacia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • PVL
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.