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Diseases

Genetic and Rare Diseases Information Center (GARD)

Scleroderma

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* Not a rare disease
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Overview

Scleroderma is an autoimmune disorder that involves changes in the skin, blood vessels, muscles, and internal organs.[1] There are two main types: localized scleroderma, which affects only the skin; and systemic scleroderma, which affects the blood vessels and internal organs, as well as the skin.[2] These two main types also have different sub-types.

Localized scleroderma can be divided in:[3]
Systemic scleroderma is subdivided in:[3][4]
There are also cases of environmentally-induced scleroderma and cases where scleroderma is part of other rheumatic disorders, like rheumatoid arthritis, lupus or Sjogren syndrome. The underlying cause of scleroderma is currently unknown; however, some scientists suspect that it may be related to a buildup of collagen in the skin and other organs due to an abnormal immune system response.[1][5] There is no cure, but various treatments can relieve symptoms.[2]
Last updated: 11/2/2015

References

  1. Borigini MJ. Scleroderma. MedlinePlus. 2014; http://www.nlm.nih.gov/medlineplus/ency/article/000429.htm.
  2. Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). 2010; http://www.niams.nih.gov/Health_Info/Scleroderma/default.asp. Accessed 10/11/2010.
  3. Denton CP. Overview and classification of scleroderma disorders. UpToDate. January 9, 2015; http://www.uptodate.com/contents/overview-and-classification-of-scleroderma-disorders.
  4. Localized scleroderma. Orphanet. July, 2010; http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=12000.
  5. Scleroderma. MayoClinic.com. 2008; http://www.mayoclinic.com/print/scleroderma/DS00362/DSECTION=all&METHOD=print. Accessed 10/11/2010.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.

Selected Full-Text Journal Articles

See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.