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Genetic and Rare Diseases Information Center (GARD)



* Not a rare disease
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How might scleroderma be treated?

Currently, there is not a cure for scleroderma, however treatments are available to relieve symptoms and limit damage. Treatment will vary depending on your symptoms.[1]

The following medications may be used to treat scleroderma:[2]

Other treatments for specific symptoms may include:[2][3][4]

  • Drugs for heartburn or swallowing problems (proton pump inhibitors)
  • Prokinetic agents to speeding the movement of food through the stomach and intestines
  • Antibiotics to address malabsorption syndrome
  • Blood pressure medications (particularly ACE inhibitors) for high blood pressure or kidney problems
  • Antihistamines and skin moisturizers to relieve itching
  • Medicines to prevent (e.g., Bosentan) or treat (e.g., iloprost) ulcers
  • Medicines to improve breathing (See: Pulmonary hypertension)
  • Medicines to treat lung scarring (e.g., cyclophosphamide)
  • Medications to treat Raynaud's phenomenon (e.g., nifedipine, iloprost)

 More detailed information regarding the treatment of scleroderma can be accessed through MedScape.

Last updated: 10/28/2014

  1. Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). 2010; Accessed 10/11/2010.
  2. Borigini MJ. Scleroderma. MedlinePlus. 2014;
  3. Denton CP. Overview of the treatment and prognosis of systemic sclerosis (scleroderma) in adults. In: Basow M, ed. UpToDate. Waltham, MA: UpToDate; 2014; Accessed 10/28/2014.
  4. Scleroderma Program. University of Michigan Health System. Accessed 10/28/2014.

GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Scleroderma. Click on the link to go to to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query".
  • The Scleroderma Clinical Trials Consortium is an international organization of scleroderma clinical researchers. The consortium Web site contains a listing of active scleroderma trials, past copies of the Scleroderma Care and Research journal, and a tool for finding your nearest member institution. 
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.