Diffuse gastric cancer
Other Names for this Disease
- Signet cell adenocarcinoma
- Signet ring gastric carcinoma
- Signet ring cell carcinoma
- Signet ring cell gastric carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 The term "signet ring cell" is often used because the cells look like signet rings when viewed under a microscope. The signet cells are a type of epithelial cell. Epithelial tissue is skin tissue, covering and lining the body both inside and out. When diffuse gastric cancer is inherited it is called "hereditary diffuse gastric cancer." Treatment depends on the stage at which the cancer is found and may include chemotherapy, radiation therapy, or operations to remove the stomach (gastrectomy).Diffuse gastric cancer or signet ring cell cancer is a type of cancer found most often in the glandular cells lining the stomach, but can also develop in the bowel, breast, pancreas, bladder, prostate or lung. The 2010 WHO (World Health Organization) classification recognizes four major histologic patterns of gastric cancers: tubular, papillary, mucinous and poorly cohesive (including signet ring cell carcinoma), plus uncommon histologic variants.
Last updated: 2/1/2016
- Hu B, El Hajj N, Sittler S, Lammert N, Barnes R & Meloni-Ehrig A. Gastric cancer: Classification, histology and application of molecular pathology. J Gastrointest Oncol. September 2012; 3(3):251-261. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418539/.
- Signet cell cancer. Cancer Research UK's Website. February 2011; http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer.
- Cabebe EC. Gastric Cancer. Medscape Reference. November, 2015; http://emedicine.medscape.com/article/278744-overview.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Diffuse gastric cancer. Click on the link to view a sample search on this topic.