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Diseases

Genetic and Rare Diseases Information Center (GARD)

Gamma heavy chain disease


Other Names for this Disease
  • Amelogenesis imperfecta type 1
  • Franklin disease
  • Gamma heavy chain deposition disease
  • Hypoplastic amelogenesis imperfecta
  • IgG heavy chain disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Gamma heavy chain disease is characterized by the abnormal production of antibodies.[1] Antibodies are made up of light chains and heavy chains. In this disorder, the heavy chain of the gamma antibody (IgG) is overproduced by the body.  Gamma heavy chain disease mainly affects older adults and is similar to aggressive malignant (cancerous) lymphoma.[2] However, some people with this disorder have no symptoms. People with symptoms may respond to chemotherapy drugs, corticosteroids, and radiation therapy.[3] Approximately one-third of individuals with gamma heavy chain disease are also diagnosed with an autoimmune disorder.[1]
Last updated: 7/25/2010

References

  1. Brick W, Faguet GB, Burgess R. Heavy Chain Disease, Gamma. eMedicine Journal. April 15, 2009; http://emedicine.medscape.com/article/200675-overview. Accessed 7/25/2010.
  2. Heavy chain diseases. Merck Manual for Healthcare Professionals. July 2008; http://www.merck.com/mmpe/sec11/ch144/ch144b.html. Accessed 7/25/2010.
  3. Heavy chain diseases. Merck Manuals Online Medical Library. July 2008; http://www.merck.com/mmhe/sec14/ch175/ch175e.html. Accessed 7/25/2010.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Merck Manual for Healthcare Professionals provides more detailed information on heavy chain diseases.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Gamma heavy chain disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Amelogenesis imperfecta type 1
  • Franklin disease
  • Gamma heavy chain deposition disease
  • Hypoplastic amelogenesis imperfecta
  • IgG heavy chain disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.