Gamma heavy chain disease
Other Names for this Disease
- Franklin disease
- Gamma heavy chain deposition disease
- IgG heavy chain disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
antibodies. Antibodies are made up of light chains and heavy chains. In this disorder, the heavy chain of the gamma antibody (IgG) is overproduced by the body. Gamma heavy chain disease mainly affects older adults and is similar to aggressive malignant (cancerous) lymphoma. However, some people with this disorder have no symptoms. People with symptoms may respond to chemotherapy drugs, corticosteroids, and radiation therapy. Approximately one-third of individuals with gamma heavy chain disease are also diagnosed with an autoimmune disorder.Gamma heavy chain disease is characterized by the abnormal production of
Last updated: 7/25/2010
- Brick W, Faguet GB, Burgess R. Heavy Chain Disease, Gamma. eMedicine Journal. April 15, 2009; http://emedicine.medscape.com/article/200675-overview. Accessed 7/25/2010.
- Heavy chain diseases. Merck Manual for Healthcare Professionals. July 2008; http://www.merck.com/mmpe/sec11/ch144/ch144b.html. Accessed 7/25/2010.
- Heavy chain diseases. Merck Manuals Online Medical Library. July 2008; http://www.merck.com/mmhe/sec14/ch175/ch175e.html. Accessed 7/25/2010.
- The Merck Manual Home Edition for Patients and Caregivers provides more information on heavy chain diseases.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Merck Manual for Healthcare Professionals provides more detailed information on heavy chain diseases.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Gamma heavy chain disease. Click on the link to view a sample search on this topic.