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Diseases

Genetic and Rare Diseases Information Center (GARD)

Immunoglobulin G deficiency

*

* Not a rare disease

Other Names for this Disease
  • IgG deficiency
  • IgG subclass deficiency
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Overview

Immunoglobulin G (IgG) deficiency is a condition that involves the immune system and is characterized by a shortage of type G antibodies. There are four different subclasses of IgG: IgG1, IgG2, IgG3, and IgG4. People with IgG deficiency may have a decreased amount of one or more of the IgG subclasses or a shortage of other types of antibodies, which may occur in various conditions including X-linked agammaglobulinemia, common variable immunodeficiency, and hyper-IgM syndrome. Individuals with IgG deficiency may have an increased susceptibility to infection, but the symptoms of this condition are variable and some people never experience any symptoms. Treatment may involve antibiotics and intravenous (IV) immunoglobulin.[1][2]
Last updated: 6/8/2016

References

  1. Robert A Schwartz, MD, MPH. Immunoglobulin G deficiency. Medscape. October 26, 2015; http://emedicine.medscape.com/article/136897-overview#a5.
  2. IgG Subclass Deficiency. Immune Deficiency Foundation. 2013; http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/igg-subclass-deficiency/.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Immunoglobulin G deficiency. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • IgG deficiency
  • IgG subclass deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.