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Diseases

Genetic and Rare Diseases Information Center (GARD)

ROHHAD


Other Names for this Disease
  • Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation
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Overview

ROHHAD is an acronym for rapid-onset obesity (RO) with hypothalamic dysregulation (H), hypoventilation (H), and autonomic dysregulation (AD). It is a rare syndrome that affects the autonomic nervous system (the part of the nervous system that controls involuntary actions) and the endocrine system. As the name suggests, the most characteristic features include dramatic weight gain over a six- to 12-month period in the first 10 years of life followed by hypothalamic dysfunction, dysregulation of the autonomic nervous system, and alveolar hypoventilation. The exact underlying cause of ROHHAD is currently unknown.[1][2] Treatment varies based on the signs and symptoms present in each person and the severity of the condition.[3][2]
Last updated: 1/9/2014

References

  1. Debra E Weese-Mayer, MD, Mary L Marazita, PhD, FACMG, Casey M Rand, BS, and Elizabeth M Berry-Kravis, MD, PhD. Congenital Central Hypoventilation Syndrome. GeneReviews. January 2014; http://www.ncbi.nlm.nih.gov/books/NBK1427/.
  2. Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation. NORD. August 2013; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/1216/viewAbstract.
  3. Ize-Ludlow D, Gray JA, Sperling MA, Berry-Kravis EM, Milunsky JM, Farooqi IS, Rand CM, Weese-Mayer DE. Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood. Pediatrics. July 2007; Accessed 11/28/2011.
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Basic Information

  • Lurie Children's Hospital has developed an information page on ROHHAD. Click on the link to access the information.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss ROHHAD. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.