Other Names for this Disease
- Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation
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syndrome that affects the autonomic nervous system (the part of the nervous system that controls involuntary actions) and the endocrine system. As the name suggests, the most characteristic features include dramatic weight gain over a six- to 12-month period in the first 10 years of life followed by hypothalamic dysfunction, dysregulation of the autonomic nervous system, and alveolar hypoventilation. The exact underlying cause of ROHHAD is currently unknown. Treatment varies based on the signs and symptoms present in each person and the severity of the condition.ROHHAD is an acronym for rapid-onset obesity (RO) with hypothalamic dysregulation (H), hypoventilation (H), and autonomic dysregulation (AD). It is a rare
Last updated: 1/9/2014
- Debra E Weese-Mayer, MD, Mary L Marazita, PhD, FACMG, Casey M Rand, BS, and Elizabeth M Berry-Kravis, MD, PhD. Congenital Central Hypoventilation Syndrome. GeneReviews. January 2014; http://www.ncbi.nlm.nih.gov/books/NBK1427/.
- Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation. NORD. August 2013; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/1216/viewAbstract.
- Ize-Ludlow D, Gray JA, Sperling MA, Berry-Kravis EM, Milunsky JM, Farooqi IS, Rand CM, Weese-Mayer DE. Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood. Pediatrics. July 2007; Accessed 11/28/2011.
- Lurie Children's Hospital has developed an information page on ROHHAD. Click on the link to access the information.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- PubMed is a searchable database of medical literature and lists journal articles that discuss ROHHAD. Click on the link to view a sample search on this topic.