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Diseases

Genetic and Rare Diseases Information Center (GARD)

Ovarian small cell carcinoma


Other Names for this Disease
  • Small cell carcinoma of the ovary
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

What treatments are available for ovarian small cell carcinoma? What specific drugs have been successfully used for chemotherapy? Are there any clinical trials?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might ovarian small cell carcinoma be treated?

There are no standard recommendations guiding the treatment of ovarian small cell carcinoma. Some authors suggest that treatment should be similar to that of other small cell carcinomas. This might include surgery to remove the tumor or tumors if appropriate, chemotherapy, and radiation therapy. Many different chemotherapy drugs have been utilized with varying rates of success including but not limited to: carboplatin, paclitaxelvinblastinecyclophosphamide, bleomycindoxorubicin, and etoposide.[1]
Last updated: 6/28/2016

What specific chemotherapy drugs have been used to treat ovarian small cell carcinoma?

Several different chemotherapy drugs have been utilized to treat ovarian small cell carcinoma. The following recently published article describes a case report in which an individual was successfully treated provides a review of previously reported treatment strategies:

Jian-jun Wang, Qi Liu, Nan Wu, Xiao-die Zhou, Hai Wang, Xuan Wang, Pin Tu, Xiao-jun Zhou, Qun-li Shi. Ovarian small-cell carcinoma hypercalcemic type successfully treated: a case report and literature review. Onco Targets Ther. 2016; 9:1409-1414. Full article available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795582

You can additionally find relevant articles on ovarian small cell carcinoma through PubMed, a searchable database of biomedical journal articles. Although not all of the articles are available for free online, most articles listed in PubMed have a summary available. To obtain the full article, contact a medical/university library or your local library for interlibrary loan. You can also order articles online through the publisher’s Web site. Using "ovarian small cell carcinoma" as your search term should help you locate articles. Use the advanced search feature to narrow your search results. Click here to view a search.
http://www.ncbi.nlm.nih.gov/PubMed

The National Library of Medicine (NLM) can help you find libraries in your area where you can get the full text of medical articles. The webpage also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can search for libraries at the following link http://nnlm.gov/members. You can also contact the NLM toll-free at 1-888-346-3656.
Last updated: 6/28/2016

Are there any clinical trials for ovarian small cell carcinoma?

The U.S. National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. Several current studies may be enrolling individuals with ovarian small cell carcinoma. After you click on a study, review its "eligibility" criteria to determine its appropriateness. Use the study’s contact information to learn more. Check this site often for regular updates.

You can also contact the Patient Recruitment and Public Liaison (PRPL) Office at the National Institutes of Health (NIH). We recommend calling the toll-free number listed below to speak with a specialist, who can help you determine if you are eligible for any clinical trials.  If you are located outside the United States, and would like to be contacted via telephone, you will need to provide your telephone number in full, including area code and international dialing prefix.

Patient Recruitment and Public Liaison Office
NIH Clinical Center
Bethesda, Maryland 20892-2655
Toll-free: 800-411-1222
Email: prpl@mail.cc.nih.gov
Web site:  http://clinicalcenter.nih.gov/

If you are interested in enrolling in a clinical trial, ClinicalTrials.gov provides general information on clinical trials.

A tutorial about clinical trials that can also help answer your questions is available from the National Library of Medicine.

The Office of Rare Diseases lists travel resources for charitable or special-fare flights to research and treatment sites and low-cost hospitality accommodations for outpatients and family members, as well as ambulance services.

Last updated: 10/12/2011

References
  • Jian-jun Wang, Qi Liu, Nan Wu, Xiao-die Zhou, Hai Wang, Xuan Wang, Pin Tu, Xiao-jun Zhou, Qun-li Shi. Ovarian small-cell carcinoma hypercalcemic type successfully treated: a case report and literature review. Onco Targets Ther. 2016; 9:1409-1414. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795582/.
Other Names for this Disease
  • Small cell carcinoma of the ovary
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.