Familial breast cancer
* Not a rare disease
Other Names for this Disease
- Breast cancer, familial
- Familial breast carcinoma
- Genetic breast cancer
- Hereditary breast cancer
- Hereditary breast carcinoma
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sporadically in people with little to no family history of the condition. Approximately 5-10% of breast cancer is considered "hereditary" and is thought to be caused by an inherited predisposition to breast cancer that is passed down through a family in an autosomal dominant manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the BRCA1, BRCA2, PTEN, TP53, CDH1, or STK11 genes (which are each associated with a unique hereditary cancer syndrome). An additional 15-20% of women diagnosed with breast cancer have a significant family history of breast cancer (two or more first-degree or second-degree relatives with breast cancer) but have no identifiable mutation in a gene known to cause a hereditary predisposition to breast cancer. These clusters of breast cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as chemoprevention and/or prophylactic surgeries are typically recommended in women who have an increased risk for breast cancer based on their personal and/or family histories.Familial breast cancer is a cluster of breast cancer within a family. Most cases of breast cancer occur
Last updated: 3/23/2015
- Genetics of Breast and Gynecologic Cancers (PDQ®). National Cancer Institute. February 2015; http://www.cancer.gov/cancertopics/pdq/genetics/breast-and-ovarian/HealthProfessional.
- Shiovitz S, Korde LA. Genetics of breast cancer: a topic in evolution. Ann Oncol. January 2015; [Epub ahead of print]:Accessed 3/18/2015.
- Economopoulou P, Dimitriadis G, Psyrri A. Beyond BRCA: new hereditary breast cancer susceptibility genes. Cancer Treat Rev. January 2015; 41(1):1-8.
- Therese Bevers, MD. Breast Cancer Screening and Diagnosis. National Comprehensive Cancer Network. January 2014; Accessed 3/23/2015.
- Genetics Home Reference (GHR) contains information on Familial breast cancer. This website is maintained by the National Library of Medicine.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
- The National Human Genome Research Institute's (NHGRI) mission encompasses a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. Click on the link to view the information page on this topic.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Familial breast cancer. Click on the link to view a sample search on this topic.