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Diseases

Genetic and Rare Diseases Information Center (GARD)

CADASIL


Other Names for this Disease
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
  • Dementia, hereditary multi-infarct type
  • Familial vascular leukoencephalopathy
  • Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy
  • CASIL
Related Diseases
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Prognosis

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What is the long-term outlook for people with CADASIL?

Symptoms usually progress slowly. By age 65, the majority of affected people have severe cognitive problems and dementia. Some people lose the ability to walk, and most become completely dependent due to multiple strokes.[1]

Data on the long-term outlook (prognosis) come from a large study of 411 people, which found that the median age at onset of inability to walk without assistance was 60 years and the median age at onset of being bedridden was 64 years. The median age at death was 68 years, with a more rapid disease progression in men than in women. At the time of death, 78% of people were completely dependent and 63% were confined to bed. Pneumonia was the most frequent cause of death.[2]
Last updated: 10/19/2015

References
  1. NINDS CADASIL Information Page. National Institute of Neurological Disorders and Stroke (NINDS). December 18, 2013; http://www.ninds.nih.gov/disorders/cadasil/CADASIL.htm. Accessed 9/29/2015.
  2. Lesnik Oberstein SAJ, Boom EMJ, Dichgans M. CADASIL. GeneReviews. July 23, 2009; http://www.ncbi.nlm.nih.gov/books/NBK1500/. Accessed 3/22/2011.


Other Names for this Disease
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
  • Dementia, hereditary multi-infarct type
  • Familial vascular leukoencephalopathy
  • Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy
  • CASIL
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.