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Diseases

Genetic and Rare Diseases Information Center (GARD)

Myoepithelial carcinoma


Other Names for this Disease
  • Malignant myoepithelioma
  • Myoepithelioma carcinoma
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Treatment

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How might myoepithelial carcinoma be treated?

The treatment for metastatic myoepithelial carcinoma usually begins with surgery to remove the main tumor.  Radiation therapy can be used to reduce the chance that the tumor could return in the same location.  Recent studies have shown that neutron-based radiation therapy may be more effective than proton-based radiation therapy for treating myoepithelial cancers.[1]

There is limited evidence about the usefulness of chemotherapy in treating metastatic myoepithelial cancer, and there are no standard treatment guidelines.  However, there are three reports of individuals with metastatic myoepithelial cancer who responded to chemotherapy.  In one individual, the metastatic tumors stopped growing during chemotherapy.[2]  In the other two individuals, there was no evidence of the metastatic tumors after 14 months for one person and after three years for the other person. [3] [4]
Last updated: 12/4/2010

References
  1. Salivary Gland Cancer Treatment: Myoepithelial carcinoma. National Cancer Institute Web site. November 19, 2010; http://www.cancer.gov/cancertopics/pdq/treatment/salivarygland/HealthProfessional/311.cdr#Section_311. Accessed 11/26/2010.
  2. Pierard S, Gregoire V, Weynand B, and Machiels JP. Epithelial-myoepithelial carcinoma of the submandibular gland with symptomatic lung metastases treated with chemotherapy. Eur Arch Otorhinolaryngol. 2006; 263:1158-1160. http://www.ncbi.nlm.nih.gov/pubmed/16896751. Accessed 12/4/2010.
  3. Puri T, Singh K, Sharma DN, and Khurana N. Epithelial-myoepithelial carcinoma of the base of tongue: Pathology and Management. Indian Journal of Cancer. 2004; 41:138-140. http://www.ncbi.nlm.nih.gov/pubmed/15472415. Accessed 12/4/2010.
  4. Noronha V, Cooper DL, Higgins SA, Murren JR, and Kluger HM. Metastatic myoepithelial carcinoma of the vulva treated with carboplatin and paclitaxel. Lancet Oncol. 2006; 7:270-271. http://www.ncbi.nlm.nih.gov/pubmed/16510337. Accessed 12/4/2010.


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Other Names for this Disease
  • Malignant myoepithelioma
  • Myoepithelioma carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.