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Diseases

Genetic and Rare Diseases Information Center (GARD)

Adrenomyeloneuropathy


Other Names for this Disease
  • AMN
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Overview

Adrenomyeloneuropathy (AMN) is an inherited condition that affects the spinal cord. It is a form of X-linked adrenoleukodystrophy. On average, people affected by AMN begin to develop features of the condition in their late twenties. Signs and symptoms may include progressive (worsening overtime) stiffness and weakness of the legs; ataxia; speech difficulties; adrenal insufficiency; sexual dysfunction; and bladder control issues. Some affected people may also have brain involvement which can lead to behavioral abnormalities, vision loss, hearing problems and/or seizures.[1][2] AMN is caused by changes (mutations) in the ABCD1 gene and is inherited in an X-linked manner.[3][4] Treatment is symptomatic and may include steroid replacement therapy for adrenal insufficiency.[2][4]
Last updated: 2/26/2015

References

  1. Adrenomyeloneuropathy (AMN). United Leukodystrophy Foundation. http://ulf.org/adrenomyeloneuropathy-amn. Accessed 2/25/2015.
  2. Alan K Percy, MD; Ronald JA Wanders, PhD. Adrenoleukodystrophy. UpToDate. February 2015; Accessed 2/25/2015.
  3. X-linked adrenoleukodystrophy. Genetics Home Reference. July 2013; http://ghr.nlm.nih.gov/condition/x-linked-adrenoleukodystrophy. Accessed 2/25/2015.
  4. Steven J Steinberg, PhD, Ann B Moser, BA, and Gerald V Raymond, MD. X-Linked Adrenoleukodystrophy. GeneReviews. April 2012; http://www.ncbi.nlm.nih.gov/books/NBK1315/.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Adrenomyeloneuropathy. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • The United Leukodystrophy Foundation has developed an information page on Adrenomyeloneuropathy. Click on the link above to view this information page.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Adrenomyeloneuropathy. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • AMN
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.