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Diseases

Genetic and Rare Diseases Information Center (GARD)

Progressive transformation of germinal centers


Other Names for this Disease
  • PTGC
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Treatment

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What treatment is available for progressive transformation of germinal centers?

Because progressive transformation of germinal centers (PTGC) is considered a benign condition and usually has no symptoms other than the enlarged lymph node, no treatment is necessary. The enlarged lymph node may stay the same size or shrink over time.[1]  Affected individuals should have regular follow-up visits with their physician; a biopsy should be taken of any new enlarged lymph node because PTGC is associated with Hodgkin lymphoma in some individuals.[2]
Last updated: 4/24/2013

References
  1. Brown JR, Skarin AT. Clinical mimics of lymphoma. The Oncologist. 2004; 9:406-416. http://www.ncbi.nlm.nih.gov/pubmed/15266094. Accessed 4/23/2013.
  2. Hicks J, Flaitz C. Progressive transformation of germinal centers: review of histopathologic and clinical features. International Journal of Pediatric Otorhinolaryngology. 2002; 65:195-202. http://www.ncbi.nlm.nih.gov/pubmed/12242134. Accessed 4/23/2013.


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    Finding Treatment Information
Other Names for this Disease
  • PTGC
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.