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Diseases

Genetic and Rare Diseases Information Center (GARD)

Pachyonychia congenita


Other Names for this Disease
  • Congenital pachyonychia
  • Pachyonychia congenita syndrome
Related Diseases
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Inheritance

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How is pachyonychia congenita inherited?

Pachyonychia congenita (PC) is inherited in an autosomal dominant manner.[1][2] This means that to be affected, a person only needs a change (mutation) in one copy of the responsible gene in each cell. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene. These cases occur in people with no history of the disorder in their family. A person with PC has a 50% chance with each pregnancy of passing along the altered gene to his or her child.
Last updated: 12/10/2015

References
  1. What is Pachyonychia Congenita?. Pachyonychia Congenita Project. http://www.pachyonychia.org/what_is_pc.php. Accessed 12/10/2015.
  2. Pachyonychia congenita. Genetics Home Reference. August 2012; http://ghr.nlm.nih.gov/condition/pachyonychia-congenita.


Other Names for this Disease
  • Congenital pachyonychia
  • Pachyonychia congenita syndrome
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.