Duane syndrome type 1
Other Names for this Disease
- Duane retraction syndrome 1
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Duane syndrome, an eye movement disorder that is present at birth. People with Duane syndrome have restricted ability to move the affected eye(s) outward toward the ear (abduction) and/or inward toward the nose (adduction). The different types are distinguished by the eye movements that are most restricted. Duane syndrome type 1 is characterized by absent to very restricted abduction and normal to mildly restricted adduction. The eye opening (palpebral fissure) narrows and the eyeball retracts into the orbit with adduction. With abduction, the reverse occurs. One or both eyes may be affected. The majority of cases are sporadic (not inherited), while about 10% are familial. 70% of affected people do not have any other abnormalities at birth (isolated Duane syndrome). Treatment is mainly supportive and may include glasses or contact lenses for vision correction, eye patches, or surgery.Duane syndrome type 1 is the most common type of
Last updated: 6/25/2016
- Caroline V Andrews, David G Hunter, and Elizabeth C Engle. Duane Syndrome. GeneReviews. March 19, 2015; http://www.ncbi.nlm.nih.gov/books/NBK1190/.
- Isolated Duane retraction syndrome. Genetics Home Reference. March 2009; http://ghr.nlm.nih.gov/condition/isolated-duane-retraction-syndrome.
- N.J. Gutowski. Duane Syndrome. NORD. 2015; http://rarediseases.org/rare-diseases/duane-syndrome/.
- The American Association for Pediatric Ophthalmology and Strabismus provides a patient information sheet on Duane syndrome type 1. Click on the link to view this information.
- The National Human Genome Research Institute's (NHGRI) website has an information page on this topic. NHGRI is part of the National Institutes of Health and supports research on the structure and function of the human genome and its role in health and disease.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Duane syndrome type 1. Click on the link to view a sample search on this topic.