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Genetic and Rare Diseases Information Center (GARD)

Hemiplegic migraine

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What are the signs and symptoms of Hemiplegic migraine?

The symptoms and severity can vary considerably among people with hemiplegic migraine. Signs and symptoms associated with aura may include:[1]
  • Visual disturbance (e.g. blind spots, flashing lights, zigzag pattern, and double vision)
  • Sensory loss (e.g., numbness or paresthesias of the face or an extremity)
  • Difficulty with speech (which usually occur along with right-sided weakness)
Motor weakness involves areas affected by sensory symptoms and varies from mild clumsiness to complete deficit. Affected people may also experience neurologic symptoms such as confusion, drowsiness, impaired consciousness, coma, psychosis, and/or memory loss. Neurologic symptoms can last for hours to days. Attention and memory loss can last weeks to months. However, permanent motor, sensory, language, or visual symptoms are extremely rare.[1]
Last updated: 11/17/2014

The Human Phenotype Ontology provides the following list of signs and symptoms for Hemiplegic migraine. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Abnormality of movement 90%
Hemiplegia/hemiparesis 90%
Incoordination 50%
Nystagmus 50%
Abnormality of retinal pigmentation 7.5%
EEG abnormality 7.5%
Neurological speech impairment 7.5%
Sensorineural hearing impairment 7.5%
Tremor 5%
Agitation -
Anxiety -
Aphasia -
Apraxia -
Ataxia -
Auditory hallucinations -
Autosomal dominant inheritance -
Blindness -
Blurred vision -
Cerebellar atrophy -
Coma -
Confusion -
Diplopia -
Drowsiness -
Dysarthria -
Dyscalculia -
Dysphasia -
Episodic ataxia -
Fever -
Hemiparesis -
Hemiplegia -
Heterogeneous -
Incomplete penetrance -
Intellectual disability -
Migraine with aura -
Photophobia -
Psychosis -
Seizures -
Transient unilateral blurring of vision -
Vertigo -
Visual hallucinations -

Last updated: 7/1/2016

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.

  1. Jen JC. Familial Hemiplegic Migraine. GeneReviews. September 2009;

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See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.