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Genetic and Rare Diseases Information Center (GARD)

Hemiplegic migraine

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Hemiplegic migraine (HM) is a rare type of migraine with aura that occurs with motor weakness during the aura. There are two types of HM which are distinguished based on the family history: familial hemiplegic migraine (FHM, in which at least one other family member has the condition) and sporadic hemiplegic migraine (SHM, in which there is no family history).[1] Signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness.[2] Severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures.[1] FHM may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner.[1][2]
Last updated: 11/17/2014


  1. Anne Ducros. Familial or sporadic hemiplegic migraine. Orphanet. April, 2008; Accessed 11/17/2014.
  2. Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. May, 2011; Accessed 8/26/2013.
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  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
    Familial hemiplegic migraine 1
    Familial hemiplegic migraine 2
    Familial hemiplegic migraine 3
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hemiplegic migraine. Click on the link to view a sample search on this topic.
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See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.