Bilateral frontal polymicrogyria
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frontal lobes without including the area located behind the Sylvius fissure or the area located behind the Rolando sulcus. Some authors classify the condition into two different forms, the bilateral frontal polymicrogyria and the bilateral frontoparietal form. Typical features included delayed motor and language milestones, spastic (stiffness) hemiparesis (weakness in one side of the body) or quadriparesis (weakness in all four limbs of the body), and mild to moderate intellectual disability. Head size is normal. Seizures may be present. The frontoparietal form is caused by a mutation in the GPR56 gene but the cause for the frontal form of polymicrogyira is still not known. Treatment is directed to the symptoms.Bilateral frontal polymicrogyria is one of the rarest subtypes of polymicrogyria. It is defined as a symmetric and bilateral form (in both brain hemispheres) of polymicrogyria that only involves the
Last updated: 10/2/2015
- Chang B, Walsh CA, Alpse K & Bodel A. Polymicrogyria Overview. Gene Review. August, 2007; http://www.ncbi.nlm.nih.gov/books/NBK1329/. Accessed 10/2/2015.
- Leventer R.J & cols. Clinical and imaging heterogeneity of polynicrogyria: a study of 328 patients. Brain. May, 2010; 133(5):1415-1427. http://brain.oxfordjournals.org/content/brain/early/2010/04/19/brain.awq078.full.pdf. Accessed 10/2/2015.
- Jansen A. & Andermann E. Genetics of the polymicrogyria syndromes. J Med Genet. 2005; 42:369–378. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736054/pdf/v042p00369.pdf. Accessed 10/2/2015.
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