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Diseases

Genetic and Rare Diseases Information Center (GARD)

Bilateral generalized polymicrogyria


Other Names for this Disease
  • Bilateral generalised polymicrogyria
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Overview

Bilateral generalized polymicrogyria is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain).[1][2][3] This is the most widespread form of polymicrogyria and typically affects the entire surface of the brain.[1] Signs and symptoms include severe intellectual disability, problems with movement, and seizures that are difficult or impossible to treat.[1][2] While the exact cause of bilateral generalized polymicrogyria is not fully understood, it is thought to be due to improper brain development during embryonic growth.[2] Most cases appear to follow an autosomal recessive pattern of inheritance. Treatment is based on the signs and symptoms present in each person.[1][2][3]
Last updated: 6/15/2015

References

  1. Polymicrogyria. Genetics Home Reference. June 2009; http://ghr.nlm.nih.gov/condition/polymicrogyria. Accessed 6/15/2015.
  2. Chang B, Walsh CA, Apse K, Bodell A. Polymicrogyria Overview. GeneReviews. August 6, 2007; http://www.ncbi.nlm.nih.gov/books/NBK1329/. Accessed 6/15/2015.
  3. Polymicrogyria. Cortical Foundation. http://cortfoundation.org/cms/get-informed/types-of-malformations/polymicrogyria/. Accessed 6/15/2015.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Bilateral generalized polymicrogyria. This website is maintained by the National Library of Medicine.

In Depth Information

  • Orphanet is a European reference portal for¬†information on rare diseases and orphan drugs.¬† Access to this database is free of charge.

Selected Full-Text Journal Articles

Other Names for this Disease
  • Bilateral generalised polymicrogyria
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.