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Diseases

Genetic and Rare Diseases Information Center (GARD)

Logopenic progressive aphasia


Other Names for this Disease
  • LPA
  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
Related Diseases
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Treatment

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How might logopenic progressive aphasia be treated?

Although no medications or interventions have demonstrated long-term stabilization of logopenic progressive aphasia (LPA), different treatment methods have shown promising short-term benefits.[1][2] Studies utilizing language therapy and behavioral interventions have shown encouraging results. Neuromodulation through methodologies such as Transcranial Direct Current Stimulation (tDCS) and transcranial magnetic stimulation (rTMS) have additionally been identified as a promising therapies to potentially use in combination with behavioral treatment and language therapy.[1]

As the most common underlying pathology of LPA is Alzheimer's disease (AD) pathology, limited research has been completed on interventions shown to reduce the rate of decline in cognitive symptoms in AD. So far cholinesterase inhibitors and memantine, medications used in Alzheimer’s disease, have not been proven effective in treating logopenic progressive aphasia. Case studies involving steriod use and Omentum Transposition Therapy have reported improvement; however, the results have not been replicated in other cases and as with other treatment options, long-term studies are lacking.[1]

The National Aphasia Association provides further information on the medical management of primary progressive aphasias at the following link:

http://live-naa.pantheon.io/wp-content/uploads/2014/12/Managing-PPA.pdf
Last updated: 4/4/2016

References
  1. Donna C. Tippett, Argye E. Hillis,Kyrana Tsapkini. Treatment of Primary Progressive Aphasia. Curr Treat Options Neurol.. August 2015; 17(8):362. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600091/.
  2. Beeson PM, King RM, Bonakdarpour B, Henry ML, Cho H, Rapcsak SZ. Positive effects of language treatment for the logopenic variant of primary progressive aphasia. J Mol Neurosci. 2011 Nov;45(3):724-36; http://www.ncbi.nlm.nih.gov/pubmed/21710364.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Logopenic progressive aphasia. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • LPA
  • Logopenic primary progressive aphasia
  • Logopenic variant PPA
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.