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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Postorgasmic illness syndrome


Other Names for this Disease
  • POIS
  • Post orgasmic sick syndrome
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Overview

Postorgasmic illness syndrome (POIS) is a condition in which affected men develop flu-like symptoms approximately 30-60 minutes after ejaculation (when semen is released from the penis). The associated symptoms typically reach their peak severity on the second day and gradually resolve within a week. Although the exact underlying cause is not well understood, some scientists believe the condition may be due to a semen allergy or chemical imbalances in the brain. Limited information is available on the treatment and management of POIS.[1][2][3]
Last updated: 4/7/2015

References

  1. Farley SJ. Postorgasmic illness syndrome. Nat Rev Urol. March 2011; 8(3):121.
  2. Waldinger MD, Meinardi MM, Schweitzer DH. Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2). J Sex Med. April 2011; 8(4):1174-1176.
  3. Jiang N, Xi G, Li H, Yin J.. Postorgasmic Illness Syndrome (POIS) in a Chinese Man: No Proof for IgE-Mediated Allergy to Semen. J Sex Med. March 2015; 12(3):840-845.
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In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Postorgasmic illness syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • POIS
  • Post orgasmic sick syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.