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Diseases

Genetic and Rare Diseases Information Center (GARD)

Postorgasmic illness syndrome


Other Names for this Disease
  • POIS
  • Post orgasmic sick syndrome
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Treatment

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How might postorgasmic illness syndrome be treated?

Unfortunately, there is currently limited information available on the treatment and management of postorgasmic illness syndrome (POIS). Some men with symptoms of POIS have been treated with SSRIs, antihistamines, and benzodiazepines.[1] One study used hyposensitization therapy to successfully treat two men with POIS. This type of therapy aims to decrease the immune response to an allergen by exposure. The men were inoculated every two weeks with increasing concentrations of their own semen. Although this therapy did not prevent symptoms entirely, both men reported a gradual improvement of symptoms over the treatment period.[2][3][1] Hyposensitization therapy may not be an option for all men with POIS, as it has been suggested that at least some cases of POIS may not be due to a semen allergy.[4]
Last updated: 6/27/2016

References
  1. Althof SE, McMahon CG. Contemporary Management of Disorders of Male Orgasm and Ejaculation. Urology. July, 2016; 93:9-21.
  2. Farley SJ. Postorgasmic illness syndrome. Nat Rev Urol. March 2011; 8(3):121.
  3. Waldinger MD, Meinardi MM, Schweitzer DH. Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2). J Sex Med. April 2011; 8(4):1174-1176.
  4. Jiang N, Xi G, Li H, Yin J.. Postorgasmic Illness Syndrome (POIS) in a Chinese Man: No Proof for IgE-Mediated Allergy to Semen. J Sex Med. March 2015; 12(3):840-845.


Other Names for this Disease
  • POIS
  • Post orgasmic sick syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.