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Diseases

Genetic and Rare Diseases Information Center (GARD)

Postorgasmic illness syndrome


Other Names for this Disease
  • POIS
  • Post orgasmic sick syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might postorgasmic illness syndrome be treated?

Unfortunately, there is limited information available on the treatment and management of men affected by postorgasmic illness syndrome (POIS). One study used hyposensitization therapy to successfully treat two men affected by POIS. These men were inoculated every two weeks with increasing concentrations of their own semen. Although this therapy did not prevent symptoms entirely, both men reported a gradual improvement over the treatment period.[1][2]

It is important to note that hyposensitization therapy may not be an option for all men affected by POIS. For example, a recent study suggests that at least some cases of POIS may not be due to a semen allergy.[3]
Last updated: 4/7/2015

References
  1. Farley SJ. Postorgasmic illness syndrome. Nat Rev Urol. March 2011; 8(3):121.
  2. Waldinger MD, Meinardi MM, Schweitzer DH. Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2). J Sex Med. April 2011; 8(4):1174-1176.
  3. Jiang N, Xi G, Li H, Yin J.. Postorgasmic Illness Syndrome (POIS) in a Chinese Man: No Proof for IgE-Mediated Allergy to Semen. J Sex Med. March 2015; 12(3):840-845.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information
Other Names for this Disease
  • POIS
  • Post orgasmic sick syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.