Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature
Other Names for this Disease
- CANDLE syndrome
- Chronic atypical neutrophilic dermatosis-lipodystrophy-elevated temperature syndrome
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autoinflammatory condition. Signs and symptoms generally develop during the first year of life and may include recurrent fevers, purpura, swollen eyelids, joint pain, contractures, developmental delay and progressive lipodystrophy. CANDLE syndrome is often caused by changes (mutations) in the PSMB8 gene and is inherited in an autosomal recessive manner. In some cases, the underlying genetic cause is unknown. There is currently no cure for the condition. Treatment is based on the signs and symptoms present in each person.Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature, also known as CANDLE syndrome, is a rare
Last updated: 11/18/2015
- Tüfekçi Ö, Bengoa S, Karapinar TH, Ataseven EB, Irken G, Ören. CANDLE syndrome: a recently described autoinflammatory syndrome. J Pediatr Hematol Oncol. 2015 May;37(4):296-9.. May 2015; 37(4):296-299.
- CANDLE syndrome. Orphanet. March 2014; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=325004.
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