Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Acquired pure red cell aplasia


Other Names for this Disease
  • Idiopathic pure red cell aplasia
  • Adult pure red cell aplasia
  • Acquired PRCA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Acquired pure red cell aplasia (PRCA) is a bone marrow disorder characterized by a reduction of red blood cells (erythrocytes) produced by the bone marrow. Signs and symptoms may include fatigue, lethargy, and/or abnormal paleness of the skin (pallor) due to the anemia the caused by the disorder.[1] In most cases, the cause of acquired PRCA is unknown (idiopathic). In other cases it may occur secondary to autoimmune disorders, tumors of the thymus gland (thymomas), hematologic cancers, solid tumors, viral infections, or certain drugs.[1][2] Treatment depends on the cause of the condition (if known) but often includes transfusions for individuals who are severely anemic and have cardiorespiratory failure.[2]
Last updated: 12/14/2011

References

  1. Pure Red Cell Aplasia, Acquired. NORD. August 7, 2007; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/506/viewAbstract. Accessed 12/14/2011.
  2. Paul Schick. Pure Red Cell Aplasia. eMedicine. October 25, 2011; http://emedicine.medscape.com/article/205695-overview. Accessed 12/14/2011.
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Your Questions Answered
Your Questions Answered
View questions about this condition answered by GARD Information Specialists. You can also submit a new question.

Basic Information

  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Acquired pure red cell aplasia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Idiopathic pure red cell aplasia
  • Adult pure red cell aplasia
  • Acquired PRCA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.