Adult-onset vitelliform macular dystrophy
Other Names for this Disease
- Macular dystrophy, vitelliform, adult-onset
- Vitelliform macular dystrophy, adult-onset
- Foveomacular dystrophy, adult-onset; AOFMD
- Foveomacular dystrophy, adult-onset, with choroidal neovascularization
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macula, which is responsible for sharp central vision. The condition causes a fatty yellow pigment to accumulate in cells underlying the macula, eventually damaging the cells. Signs and symptoms usually begin between ages 30 and 50 and include blurred and/or distorted vision, which can progress to central vision loss over time.Historically, AVMD has been characterized as a genetic disorder caused by mutations in the PRPH2, BEST1, IMPG1, and IMPG2 genes; however, recent studies focused on genetic testing suggest that there may be other unidentified genes and/or environmental causes.The majority of cases due to a mutation in the identified genes are inherited in an autosomal dominant manner; however not all individuals have AVMD have a family history and not all individuals who inherit a causative gene mutation develop symptoms.Adult-onset vitelliform macular dystrophy (AVMD) is an eye disorder that can cause progressive vision loss. AVMD affects an area of the retina called the
Last updated: 3/8/2016
- Vitelliform macular dystrophy. Genetics Home Reference. December 2013; http://ghr.nlm.nih.gov/condition/vitelliform-macular-dystrophy.
- Cassandra L. Kniffin. MACULAR DYSTROPHY, VITELLIFORM, ADULT-ONSET. OMIM. 2/18/2015; http://omim.org/entry/608161.
- Do P, Ferrucci . Adult-onset foveomacular vitelliform dystrophy. Optometry. April 2006; 77(4):156-166.
- Liran Tiusano, Michelle Grunin, Shira Hagbi-Levi, Eyal Banin, Edward Averbukh, and Italy Chowers. Characterising the phenotype and progression of sporadic adult-onset foveomacular vitelliform dystrophy. British Journal of Opthalmology. January 22, 2016; 1-6. http://www.ncbi.nlm.nih.gov/pubmed/26802173.
- Itay Chowersa, Liran Tiosanoa, Isabelle Audoc, Michelle Grunina, Camiel J.F. Boon. Adult-onset foveomacular vitelliform dystrophy: A fresh perspective. Progress in Retinal and Eye Research. February 2015; 47:64-85. http://www.ncbi.nlm.nih.gov/pubmed/25681578.
- Genetics Home Reference (GHR) contains information on Adult-onset vitelliform macular dystrophy. This website is maintained by the National Library of Medicine.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Adult-onset vitelliform macular dystrophy. Click on the link to view a sample search on this topic.