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Diseases

Genetic and Rare Diseases Information Center (GARD)

Disseminated superficial actinic porokeratosis


Other Names for this Disease
  • DSAP
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Overview

Disseminated superficial actinic porokeratosis (DSAP) is a skin condition that causes dry patches.[1] It is characterized by a large number of small, brownish patches with a distinctive border, found most commonly on sun-exposed areas of the skin (particularly the arms and legs).[1][2] DSAP usually starts during the third or fourth decade of life and rarely affects children. Lesions usually appear in summer and improve or disappear during winter. While it is usually benign (not cancerous), squamous cell carcinoma or Bowen’s disease may occasionally develop within patches.[3] DSAP may be inherited in an autosomal dominant matter or may occur sporadically (in people with no family history of DSAP).[3] Some cases are caused by a change (mutation) in the MVK or SART3 genes.[3][4] Treatment is generally not effective long-term but may include sun protection, topical medications, cryotherapy, and/or photodynamic therapy.[1][3]
Last updated: 3/12/2015

References

  1. Disseminated superficial actinic porokeratosis. DermNet NZ. September 23, 2014; http://www.dermnetnz.org/scaly/dsap.html. Accessed 3/12/2015.
  2. Disseminated superficial actinic porokeratosis. Orphanet. February, 2014; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=79152. Accessed 3/12/2015.
  3. Isabelle Touitou et. al. The expanding spectrum of rare monogenic autoinflammatory diseases. Orphanet Journal of Rare Diseases. 2013; 8:162:http://www.ojrd.com/content/8/1/162.
  4. Linda V Spencer. Porokeratosis. Medscape. September 9, 2014; http://emedicine.medscape.com/article/1059123-overview. Accessed 3/12/2015.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Disseminated superficial actinic porokeratosis. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • DSAP
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.