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Diseases

Genetic and Rare Diseases Information Center (GARD)

Febrile infection-related epilepsy syndrome


Other Names for this Disease
  • FIRES
  • Acute encephalitis with refractory repetitive partial seizures
  • AERRPS
  • Acute non-herpetic encephalitis with severe refractory status epilepticus
  • Devastating epileptic encephalopathy in school-aged children
Related Diseases
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Overview

Febrile infection-related epilepsy syndrome (FIRES) is a severe brain disorder that develops in children after a fever. This condition results in sudden seizures and leads to declines in memory and intellectual ability. FIRES can also cause psychiatric disorders or problems with motor skills. The cause of FIRES is unknown, but may be related to infection, genetic susceptibility, an autoimmune disorder, or a problem with metabolism. Treatment involves antiepileptic medications to manage seizures, but they do not usually work well.[1]
Last updated: 3/19/2013

References

  1. Van Baalen A. Febrile infection-related epilepsy syndrome. Orphanet. July 2012; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=163703. Accessed 3/19/2013.
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In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Febrile infection-related epilepsy syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • FIRES
  • Acute encephalitis with refractory repetitive partial seizures
  • AERRPS
  • Acute non-herpetic encephalitis with severe refractory status epilepticus
  • Devastating epileptic encephalopathy in school-aged children
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.