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Diseases

Genetic and Rare Diseases Information Center (GARD)

Recurrent respiratory papillomatosis


Other Names for this Disease
  • RRP
  • Juvenile laryngeal papilloma
  • Laryngeal papilloma, recurrent
  • Juvenile-onset recurrent respiratory papillomatosis (type)
  • JORRP (type)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might recurrent respiratory papillomatosis be treated?

There is no cure for recurrent respiratory papillomatosis. Surgery is the primary method for removing tumors from the larynx or airway. Because traditional surgery can result in problems due to scarring of the larynx tissue, many surgeons are now using laser surgery, which uses an intense laser light as the surgical tool. Carbon dioxide lasers—which pass electricity through a tube containing carbon dioxide and other gases to generate light—are currently the most popular type used for this purpose. In the past 10 years, surgeons have begun using a device called a microdebrider, which uses suction to hold the tumor while a small internal rotary blade removes the growth.[1]

Once the tumors have been removed, they have a tendency to return. It is common for affected individuals to require repeat surgery. In the most extreme cases where tumor growth is aggressive, a tracheostomy may be performed.[1]

Adjuvant therapies—therapies that are used in addition to surgery—have been used to treat more severe cases of RRP. Drug treatments may include antivirals such as interferon and cidofovir, which block the virus from making copies of itself, and indole-3-carbinol, a cancer-fighting compound found in cruciferous vegetables, such as broccoli and Brussels sprouts. To date, the results of these and other adjuvant therapies have been mixed or not yet fully proven.[1]

Two articles from eMedicine Journal provides comprehensive information on treatment for recurrent respiratory papillomatosis at the following links. You may need to register to view these articles, but registration is free.
http://emedicine.medscape.com/article/302648-treatment#showall
http://emedicine.medscape.com/article/865758-treatment#showall
Last updated: 11/21/2011

References
  1. Recurrent Respiratory Papillomatosis or Laryngeal Papillomatosis. National Institute on Deafness and Other Communication Disorders. October 2010; http://www.nidcd.nih.gov/health/voice/pages/laryngeal.aspx. Accessed 11/21/2011.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Recurrent respiratory papillomatosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • RRP
  • Juvenile laryngeal papilloma
  • Laryngeal papilloma, recurrent
  • Juvenile-onset recurrent respiratory papillomatosis (type)
  • JORRP (type)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.