Primary melanoma of the central nervous system
Other Names for this Disease
- Primary CNS melanoma
- Primary melanoma of the CNS
- Primary meningeal melanoma
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Although the exact cause of this condition is unknown, researchers have identified somatic mutations in the the GNAQ gene in 7 of 19 patients (37 percent) with primary malignant melanocytic tumors of the central nervous system. Somatic mutations are not inherited but occur during a person's lifetime. This mutation makes the Gnaq protein constantly active. The same mutation has been identified in approximately half of patients with intraocular melanoma.
Last updated: 2/21/2014
- Küsters-Vandevelde HV1 et al. Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system. Acta Neuropathol. March 2010; 119(3):317-323. http://www.ncbi.nlm.nih.gov/pubmed?term=19936769.