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Diseases

Genetic and Rare Diseases Information Center (GARD)

Melanoma-associated retinopathy


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Overview

Melanoma-associated retinopathy (MAR) is a rare autoimmune condition that occurs in some people with melanoma (a type of skin cancer) and can affect the vision. Signs and symptoms of MAR may include night blindness; photopsia (presence of perceived flashes of light); and progressive, painless vision loss. MAR occurs when the body's immune system, in response to melanoma, mistakenly attacks the cells of the retina; however, it is poorly understood why this autoimmune response occurs in some people but not others. There is, unfortunately, no established treatment for MAR. Proposed strategies for treatment include immunosuppressive medications and/or standard treatment of the melanoma (i.e. surgery, chemotherapy, and/or radiation therapy).[1][2][3]
Last updated: 12/30/2015

References

  1. Raj K Maturi, MD. Cancer Associated and Related Autoimmune Retinopathies. Medscape Reference. March 2014; http://emedicine.medscape.com/article/1227724-overview#a1.
  2. Dabir S, Mangalesh S, Govindraj I, Mallipatna A, Battu R, Shetty R. Melanoma associated retinopathy: A new dimension using adaptive optics. Oman J Ophthalmol. May-Aug 2015; 8(2):125-127.
  3. Audemard A, de Raucourt S, Miocque S, Comoz F, Giraud JM, Dreno B, Bienvenu B, Rogerie MJ, Dompmartin A. Melanoma-associated retinopathy treated with ipilimumab therapy. Dermatology. 2013; 227(2):146-149.
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In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Melanoma-associated retinopathy. Click on the link to view a sample search on this topic.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.