Other Names for this Disease
- Stargardt macular dystrophy
- Juvenile onset macular degeneration
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lipofuscin) in the cells within the macula. People with Stargardt disease also have problems with night vision, and some have problems with color vision. The signs and symptoms of Stargardt disease typically appear in late childhood to early adulthood and worsen over time. It is most commonly caused by mutations in the ABCA4 gene and inherited in an autosomal recessive manner. Rarely it may be caused by mutations in other genes and inherited in an autosomal dominant manner. There is currently no treatment, but various services and devices can help affected people carry out daily activities and maintain their independence.Stargardt disease is a genetic eye disorder that causes progressive vision loss. It affects the macula, an area of the retina responsible for sharp, central vision. Vision loss is due to abnormal accumulation of a fatty yellow pigment (
Last updated: 3/7/2016
- Stargardt macular degeneration. Genetics Home Reference. November 2010; http://ghr.nlm.nih.gov/condition/stargardt-macular-degeneration.
- Jane Kelly. STARGARDT DISEASE 1; STGD1. OMIM. June 8, 2015; http://www.omim.org/entry/248200.
- Facts About Stargardt Disease. NEI. April, 2015; https://nei.nih.gov/health/stargardt/star_facts.
- The American Society of Gene & Cell Therapy provides information on the treatment of genetic eye diseases.
- Foundation Fighting Blindness provides information about Stargardt disease and other retinal diseases.
- Genetics Home Reference (GHR) contains information on Stargardt disease. This website is maintained by the National Library of Medicine.
- The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Stargardt disease. Click on the link to view a sample search on this topic.