Transient neonatal diabetes mellitus
Other Names for this Disease
- Diabetes mellitus, transient neonatal
- Chromosome 6-associated transient diabetes mellitus
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diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited. Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes. Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.Transient neonatal diabetes mellitus (TNDB) is a type of
Last updated: 8/28/2012
- Michel Polak. Neonatal diabetes mellitus. Orphanet. March 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=224. Accessed 8/24/2012.
- Permanent neonatal diabetes mellitus. Genetics Home Reference. July 2011; http://ghr.nlm.nih.gov/condition/permanent-neonatal-diabetes-mellitus. Accessed 8/24/2012.
- Isabel Karen Temple and Deborah JG Mackay. Diabetes Mellitus, 6q24-Related Transient Neonatal. GeneReviews. December 23, 2010; http://www.ncbi.nlm.nih.gov/books/NBK1534/. Accessed 8/24/2012.
- 6q24-related transient neonatal diabetes mellitus. Genetics Home Reference. February 2011; http://ghr.nlm.nih.gov/condition/6q24-related-transient-neonatal-diabetes-mellitus. Accessed 8/28/2012.
- Genetics Home Reference (GHR) contains information on Transient neonatal diabetes mellitus. This website is maintained by the National Library of Medicine.
- The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
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- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
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