Transient neonatal diabetes mellitus
Other Names for this Disease
- Diabetes mellitus, transient neonatal
- Chromosome 6-associated transient diabetes mellitus
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diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited. Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes. Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.Transient neonatal diabetes mellitus (TNDB) is a type of
Last updated: 8/28/2012
- Michel Polak. Neonatal diabetes mellitus. Orphanet. March 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=224. Accessed 8/24/2012.
- Permanent neonatal diabetes mellitus. Genetics Home Reference. July 2011; http://ghr.nlm.nih.gov/condition/permanent-neonatal-diabetes-mellitus. Accessed 8/24/2012.
- Isabel Karen Temple and Deborah JG Mackay. Diabetes Mellitus, 6q24-Related Transient Neonatal. GeneReviews. December 23, 2010; http://www.ncbi.nlm.nih.gov/books/NBK1534/. Accessed 8/24/2012.
- 6q24-related transient neonatal diabetes mellitus. Genetics Home Reference. February 2011; http://ghr.nlm.nih.gov/condition/6q24-related-transient-neonatal-diabetes-mellitus. Accessed 8/28/2012.
- Genetics Home Reference (GHR) contains information on Transient neonatal diabetes mellitus. This website is maintained by the National Library of Medicine.
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- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
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