Other Names for this Disease
- Dysfibrinogenemia, familial
- Congenital dysfibrinogenemia
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 Dysfibrinogenemia may increase a person's risk of venous thrombosis or rarely cause a mild bleeding tendency. PT, PTT, and Thrombin Time tests are used to screen for this condition, which is then confirmed with additional specialized blood tests. Patients with dysfibrinogenemia may experience poor wound healing. Hereditary transmission is autosomal dominant or codominant except in a few cases that appear to be transmitted recessively.Dysfibrinogenemia is a rare coagulation disorder caused by a mutation in the gene controlling the production of fibrinogen in the liver. It causes the liver to make an abnormal fibrinogen, one that resists degradation when converted to fibrin.
Last updated: 12/9/2009
- Fibrinogen. Lab Tests Online. 2009; http://www.labtestsonline.org/understanding/analytes/fibrinogen/test.html. Accessed 12/9/2009.
- Mosesson MW. Hereditary Abnormalities of Fibrinogen. In: Beutler E, Lichtman M, Coller BS, Kipps TJ, Geligsohn U. Williams Hematology, 6th ed.. NY: McGraw-Hill; 2001;
- Brick W, Burgess R, Faguet GB. Dysfibrinogenemia. eMedicine. 2009; http://emedicine.medscape.com/article/199723-overview. Accessed 12/9/2009.
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- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Dysfibrinogenemia. Click on the link to view a sample search on this topic.