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Diseases

Genetic and Rare Diseases Information Center (GARD)

Fowler's syndrome


Other Names for this Disease
  • Voiding dysfunction and polycystic ovaries
  • Polycystic ovaries urethral sphincter dysfunction
  • Fowler Christmas Chapple syndrome
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Treatment

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How might Fowler’s syndrome be treated?

The urinary incontinence caused by Fowler’s syndrome may be treated by sacral neuromodulation therapy.[1] The success rate for treatment of Fowler’s syndrome with neuromodulation has been estimated to be around 70%, even in women who have been experiencing symptoms for a while.[2]

Neuromodulation therapy involves the stimulation of nerves to the bladder leaving the spine. The FDA has approved a device called InterStim for this purpose. Your doctor will need to test to determine if this device would be helpful to you. The doctor applies an external stimulator to determine if neuromodulation works in you. If you have a 50 percent reduction in symptoms, a surgeon will implant the device. Although neuromodulation can be effective, it is not for everyone. The therapy is expensive, involving surgery with possible surgical revisions and replacement.[2]

Other treatments that have been tried with little success include hormonal manipulation, pharmacologic therapy, and injections of botulinum toxin.[1]

Last updated: 12/31/2013

References
  1. Wein Aj. Lower Urinary Tract Dysfunction in Neurologic Injury and Disease. In: Wein et al. Campbell-Walsh Urology, 9th ed. Philadelphia, PA: Saunders; 2007;
  2. Urinary Incontinence in Women. National Institute of Diabetes and Digestive and Kidney Diseases. September 18, 2013; http://kidney.niddk.nih.gov/kudiseases/pubs/uiwomen/index.htm. Accessed 12/31/2013.


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Other Names for this Disease
  • Voiding dysfunction and polycystic ovaries
  • Polycystic ovaries urethral sphincter dysfunction
  • Fowler Christmas Chapple syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.