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Diseases

Genetic and Rare Diseases Information Center (GARD)

Menetrier disease


Other Names for this Disease
  • Giant hypertrophic gastritis
  • Giant hypertrophic gastropathy
  • Gastroenteropathy, protein losing
  • Giant hypertrophy of the gastric mucosa
  • Hypertrophic gastropathy
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Overview

Ménétrier disease is a gastrointestinal condition characterized by overgrowth of the mucous cells (foveola) in the mucous membrane lining the stomach, causing enlarged gastric folds.[1] This leads to excessive mucus production, causing protein loss from the stomach and low or absent levels of stomach acid.[2] Symptoms may include pain in the upper middle region of the stomach, nausea, vomiting, and diarrhea.[1] The cause of Ménétrier disease is largely not known, although some cases are associated with infection, particularly pediatric cases, which can be caused by CMV infections. Treatment may include medications such as cetuximab and gastrectomy in severe cases.[1][2]
Last updated: 6/1/2016

References

  1. Nicholas J. Talley, John Y. Kao. Menetrier Disease. NORD. 2010; http://rarediseases.org/rare-diseases/menetrier-disease/. Accessed 6/1/2016.
  2. Ménétrier’s Disease. National Institute of Diabetes and Digestive and Kidney Disease. March 2014; http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/menetriers-disease/Pages/facts.aspx.
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Basic Information

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Menetrier disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Giant hypertrophic gastritis
  • Giant hypertrophic gastropathy
  • Gastroenteropathy, protein losing
  • Giant hypertrophy of the gastric mucosa
  • Hypertrophic gastropathy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.