Other Names for this Disease
- Rapidly progressive glomerulonephritis with pulmonary hemorrhage
- Anti-glomerular basement membrane antibody disease
- Glomerulonephritis - pulmonary hemorrhage
- Pulmonary renal syndrome
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glomerulonephritis. Some use the term "Goodpasture syndrome" for the findings of glomerulonephritis and pulmonary hemorrhage and the term "Goodpasture disease" for those patients with glomerulonephritis, pulmonary hemorrhage, and anti-GBM antibodies. Currently, the preferred term for both conditions is “anti-GBM antibody disease”. Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), thereby resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveolus) resulting in bleeding of the lung (pulmonary hemorrhage). Anti-GBM antibody disease is most often idiopathic, although it can occasionally follow pulmonary infections or be associated with pulmonary injury. Diagnosis is confirmed with the presence of anti-GBM antibody in blood or in the kidney. The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide.Goodpasture syndrome is an autoimmune disease of unknown cause that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs), and a kidney disease known as
Last updated: 9/22/2015
- Anti-Glomerular Basement Membrane Disease. Medical Subject Headings. 2008; http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?mode=&index=18489&view=expanded. Accessed 9/22/2015.
- Valentini RP. Pediatric Anti-GBM Disease (Goodpasture Syndrome). Medscape Reference. March 5, 2015; http://www.emedicine.com/ped/TOPIC888.HTM. Accessed 9/22/2015.
- Kathuria P. Goodpasture Syndrome. Mescape Reference. December 12, 2014; http://emedicine.medscape.com/article/240556-overview. Accessed 9/22/2015.
- Pusey CD & Kalluri R. Pathogenesis and diagnosis of anti-GBM antibody (Goodpasture's) disease. UpToDate. November 25, 2013; http://www.uptodate.com/contents/pathogenesis-and-diagnosis-of-anti-gbm-antibody-goodpastures-disease. Accessed 9/22/2015.
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- The National Kidney Foundation, Inc. offers an information page on Goodpasture syndrome.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
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- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Goodpasture syndrome. Click on the link to view a sample search on this topic.