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Diseases

Genetic and Rare Diseases Information Center (GARD)

Goodpasture syndrome


Other Names for this Disease
  • Rapidly progressive glomerulonephritis with pulmonary hemorrhage
  • Anti-glomerular basement membrane antibody disease
  • Glomerulonephritis - pulmonary hemorrhage
  • Pulmonary renal syndrome
  • Anti-GBM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might Goodpasture syndrome be treated?

The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide. The three main goals for the treatment are:[1][2][3] 

1. Rapidly remove circulating antibody, primarily by plasmapheresis.

2. Stop further production of antibodies using immunosuppression with medications, namely, corticosteroids (e.g., prednisone) and cyclophosphamide. In children, plasmapheresis is done together with corticosteroids and cyclophosphamide. The duration of the immunosuppressive treatment varies but is typically 6 months for corticosteroids and 3 months for cyclophosphamide.

3. Remove offending agents that may have initiated the antibody production.

After hospital discharge, patients require long-term regular visits for monitoring kidney function and for immunosuppressive therapy. If kidney function does not return, dialysis is continued indefinitely and the patient should be referred for kidney transplantation.

If the person smokes, it is recommended he or she stop. Also, if the patient is exposed to hydrocarbon in his or her occupation, he or she should consider changing jobs, as exposure to hydrocarbon has been shown to increase a person's chances of disease recurrence.[3]
Last updated: 9/22/2015

References
  1. Anti-Glomerular Basement Membrane Disease. Medical Subject Headings. 2008; http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?mode=&index=18489&view=expanded. Accessed 9/22/2015.
  2. Valentini RP. Pediatric Anti-GBM Disease (Goodpasture Syndrome). Medscape Reference. March 5, 2015; http://www.emedicine.com/ped/TOPIC888.HTM. Accessed 9/22/2015.
  3. Kathuria P. Goodpasture Syndrome. Mescape Reference. December 12, 2014; http://emedicine.medscape.com/article/240556-overview. Accessed 9/22/2015.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Clinical Trials & Research for this Disease

  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query".
Other Names for this Disease
  • Rapidly progressive glomerulonephritis with pulmonary hemorrhage
  • Anti-glomerular basement membrane antibody disease
  • Glomerulonephritis - pulmonary hemorrhage
  • Pulmonary renal syndrome
  • Anti-GBM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.