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Diseases

Genetic and Rare Diseases Information Center (GARD)

Goodpasture syndrome


Other Names for this Disease
  • Rapidly progressive glomerulonephritis with pulmonary hemorrhage
  • Anti-glomerular basement membrane antibody disease
  • Glomerulonephritis - pulmonary hemorrhage
  • Pulmonary renal syndrome
  • Anti-GBM syndrome
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Overview

Goodpasture syndrome is an autoimmune disease of unknown cause that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs), and a kidney disease known as glomerulonephritis. Some use the term "Goodpasture syndrome" for the findings of glomerulonephritis and pulmonary hemorrhage and the term "Goodpasture disease" for those patients with glomerulonephritis, pulmonary hemorrhage, and anti-GBM antibodies. Currently, the preferred term for both conditions is “anti-GBM antibody disease”. Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), thereby resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveolus) resulting in bleeding of the lung (pulmonary hemorrhage). Anti-GBM antibody disease is most often idiopathic, although it can occasionally follow pulmonary infections or be associated with pulmonary injury. Diagnosis is confirmed with the presence of anti-GBM antibody in blood or in the kidney. The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide.[1][2][3][4]
Last updated: 9/22/2015

References

  1. Anti-Glomerular Basement Membrane Disease. Medical Subject Headings. 2008; http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?mode=&index=18489&view=expanded. Accessed 9/22/2015.
  2. Valentini RP. Pediatric Anti-GBM Disease (Goodpasture Syndrome). Medscape Reference. March 5, 2015; http://www.emedicine.com/ped/TOPIC888.HTM. Accessed 9/22/2015.
  3. Kathuria P. Goodpasture Syndrome. Mescape Reference. December 12, 2014; http://emedicine.medscape.com/article/240556-overview. Accessed 9/22/2015.
  4. Pusey CD & Kalluri R. Pathogenesis and diagnosis of anti-GBM antibody (Goodpasture's) disease. UpToDate. November 25, 2013; http://www.uptodate.com/contents/pathogenesis-and-diagnosis-of-anti-gbm-antibody-goodpastures-disease. Accessed 9/22/2015.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.
  • The National Kidney Foundation, Inc. offers an information page on Goodpasture syndrome.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Goodpasture syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Rapidly progressive glomerulonephritis with pulmonary hemorrhage
  • Anti-glomerular basement membrane antibody disease
  • Glomerulonephritis - pulmonary hemorrhage
  • Pulmonary renal syndrome
  • Anti-GBM syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.