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Diseases

Genetic and Rare Diseases Information Center (GARD)

Hepatoblastoma


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Overview

Hepatoblastoma is a rare malignant (cancerous) tumor of the liver that usually occurs in the first 3 years of life. In early stages of the condition, there may be no concerning signs or symptoms. As the tumor gets larger, affected children may experience a painful, abdominal lump; swelling of the abdomen; unexplained weight loss; loss of appetite; and/or nausea and vomiting. The exact underlying cause of hepatoblastoma is poorly understood. Risk factors for the tumor include prematurity with a very low birth weight, early exposure to hepatitis B infection, biliary atresia, and several different genetic conditions (i.e. Beckwith-Wiedemann syndrome, familial adenomatous polyposis, Aicardi syndrome, Glycogen storage disease, and Simpson-Golabi-Behmel syndrome). Treatment varies based on the severity of the condition but may include a combination of surgery, watchful waiting, chemotherapy, and/or radiation therapy.[1][2][3]
Last updated: 1/20/2016

References

  1. Jennifer Reikes Willert, MD. Pediatric Hepatoblastoma. Medscape Reference. November 2014; http://emedicine.medscape.com/article/986802-overview.
  2. Childhood Liver Cancer Treatment (PDQ®). National Cancer Institute. December 2015; http://www.cancer.gov/types/liver/patient/child-liver-treatment-pdq#section/_1.
  3. Devi LP1, Kumar R, Handique A, Kumar M. Hepatoblastoma--a rare liver tumor with review of literature. J Gastrointest Cancer. December 2014; 45 Suppl 1:261-264.
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Basic Information

  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.