- Hypereosinophilic syndrome, idiopathic
Your QuestionMy younger brother was recently diagnosed with hypereosinophilic (HES) syndrome. I would like to know if this condition has a genetic element.
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Questions on this page
- What is hypereosinophilic syndrome?
- Is hypereosinophilic syndrome genetic?
- Is hypereosinophilic syndrome hereditary?
- What is familial eosinophilia?
- Has the gene that causes familial eosinophilia been identified? How is the condition inherited?
- Who might I speak to if I am interested in determining whether familial eosinophilia is present in my family?
- How can I find additional information and supportive resources for hypereosinophilic syndrome?
In the case of hypereosinophilic syndrome, some cases have been discovered to be genetic, but not hereditary. There are also cases of hyperosinophilic syndrome that have been found to be both genetic and hereditary and are frequently referred to as familial eosinophilia.
Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference at http://ghr.nlm.nih.gov/handbook/consult. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.
The following online resources can help you find a genetics professional in your community:
- GeneTests has a searchable directory of US and international genetics and prenatal diagnosis clinics.
- The National Society for Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.
- Hypereosinophilic syndrome. DermNet NZ. June 15, 2009; http://dermnetnz.org/systemic/hypereosinophilic.html. Accessed 6/22/2009.
- Hypereosinophilic syndrome. Apfed Official Web site of the American Partnership for Eosinophilic Disorders. October 14, 2006; http://www.apfed.org/hes.htm. Accessed 6/22/2009.
- Hypereosinophilic syndrome, idiopathic. OMIM (Online Mendelian Inheritance in Man). December 18, 2003; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607685. Accessed 6/22/2009.
- Rioux JD, Stone VA, Daly MJ, Cargill M, Green T, Nguyen H et al. Familial Eosinophilia Maps to the Cytokine Gene Cluster on Human Chromosomal Region 5q31-q33. Am. J. Hum. Genet.. 1998;
- Klion AD, Law MA, Riemenschneider W, McMaster ML, Brown MR, Horne M et al. Familial eosinophilia: a benign disorder?. Blood. 1 June 2004;