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Diseases

Genetic and Rare Diseases Information Center (GARD)

Iridogoniodysgenesis type 1


Other Names for this Disease
  • Iridogoniodysgenesis anomaly, Autosomal dominant
  • IRID1
  • IGDA
  • IGDA syndrome
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Overview

Iridogoniodysgenesis type 1 is a rare condition that affects the eyes. People with this condition are born with malformations of the iris (the colored part of the eye) and cornea, which eventually lead to early-onset glaucoma. The irides of affected people are unusually dark. For example, studies of the condition often describe 'brown' irides as a dark, chocolate color and 'blue' irides as a very dark, slate gray. The iris also lacks the usual pattern and has a smooth appearance. Iridogoniodysgenesis type 1 is caused by changes (mutations) in the FOXC1 gene and is inherited in an autosomal dominant manner.[1][2] Management is based on the signs and symptoms present in each person and is generally focused on the screening and eventual treatment of glaucoma.[1]
Last updated: 3/22/2016

References

  1. Iridogoniodysgenesis, Type 1. University of Arizona College of Medicine, Department of Ophthalmology and Vision Science. http://disorders.eyes.arizona.edu/disorders/iridogoniodysgenesis-type-1. Accessed 3/22/2016.
  2. IRIDOGONIODYSGENESIS, TYPE 1. OMIM. March 2011; http://www.omim.org/entry/601631.
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In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Iridogoniodysgenesis type 1. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Iridogoniodysgenesis anomaly, Autosomal dominant
  • IRID1
  • IGDA
  • IGDA syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.