Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Iridogoniodysgenesis type 2


Other Names for this Disease
  • IRID2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Iridogoniodysgenesis type 2 is a rare condition that affects the eyes. People with this condition are born with malformations of the iris (the colored part of the eye) and cornea, which eventually lead to early-onset glaucoma. The irides of affected people are unusually dark. For example, studies of the condition often describe 'brown' irides as a dark, chocolate color and 'blue' irides as a very dark, slate gray. The iris also lacks the usual pattern and has a smooth appearance. Iridogoniodysgenesis type 2 is caused by changes (mutations) in the PITX2 gene and is inherited in an autosomal dominant manner.[1][2] Management is based on the signs and symptoms present in each person and is generally focused on the screening and eventual treatment of glaucoma.[1]
Last updated: 3/22/2016

References

  1. Iridogoniodysgenesis, Type 2. University of Arizona College of Medicine, Department of Ophthalmology and Vision Science. http://disorders.eyes.arizona.edu/disorders/iridogoniodysgenesis-type-2. Accessed 3/22/2016.
  2. IRIDOGONIODYSGENESIS, TYPE 2. OMIM. October 2009; http://www.omim.org/entry/137600.
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Contact GARD
Contact GARD
Contact a GARD Information Specialist with your questions about this condition.
On this page

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Iridogoniodysgenesis type 2. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • IRID2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.