Ceroid lipofuscinosis neuronal 2
Other Names for this Disease
- CLN2 disease
- CLN2 disease, juvenile (subtype)
- CLN2 disease, late infantile (subtype)
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neuronal ceroid lipofuscinoses (NCLs). The NCLs are characterized by an abnormal accumulation of lipopigments, which are substances made up of fats and proteins within the brain’s nerve cells, eyes, skin, muscle, and other tissues throughout the body. CLN2 causes nerve cells, found in the brain, retina, and central nervous system, to die. Symptoms typically begin between ages 2 and 4. Early signs may include loss of muscle coordination (ataxia) and seizures that do not respond to drugs. This form progresses rapidly and ends in death between ages 8 and 12. The condition is caused by mutations in the CLN 2 gene which lead to deficient activity of the TPP1 enzyme.Ceroid lipofuscinosis, neuronal 2 (CLN2) / late infantile neuronal ceroid lipofuscinosis (LINCL) / Jansky-Bielschowsky / late infantile CLN2/TPP1 disorder is part of a group of progressive degenerative neurometabolic disorders known as the
Last updated: 7/15/2009
- Jansky-Bielschowsky/Late Infantile CLN2/TPP1 Disease. Hide & Seek Foundation for Lysosomal Disease Research. http://www.hideandseek.org/index.php?option=com_content&task=view&id=130. Accessed 7/15/2009.
- Batten Disease Fact Sheet. National Institute of Neurological Disorders and Stroke (NINDS). 2009; http://www.ninds.nih.gov/disorders/batten/detail_batten.htm. Accessed 7/15/2009.
- The Hide & Seek Foundation for Lysosomal Storage Disease Research provides information about ceroid lipofuscinosis, neuronal 2. Click on the link to view this information.
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