Punctate palmoplantar keratoderma type I
- Buschke fischer brauer syndrome
- Keratodermia palmoplantaris papulosa, Buschke-Fischer-Brauer type
- Type I punctate palmoplantar keratoderma
- Keratoderma, palmoplantar punctate type 1
- Buschke-Fischer-Brauer syndrome
Your QuestionMy father has Buschke Fischer keratoderma palmo-plantaris. Is there any treatment for this condition?
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Questions on this page
- What is punctate palmoplantar keratoderma type I?
- What are the signs and symptoms of punctate palmoplantar keratoderma type 1?
- What causes palmoplantar keratoderma type 1?
- How is punctate palmoplantar keratoderma type I inherited?
- How is punctate palmoplantar keratoderma type I diagnosed?
- How might punctate palmoplantar keratoderma type 1 be treated?
- How can I find a genetics professional in my area?
In some families, punctate palmoplantar keratoderma type 1 appears to be associated with an increased risk for several types of cancer.
Autosomal dominant inheritance is when only one mutated copy of a disease-causing gene in each cell is sufficient for a person to be affected. An autosomal dominant condition may occur for the first time in an affected individual due to a new mutation, or may be inherited from an affected parent. When a person with an autosomal dominant disorder has a child, there is a 50% chance that his/her child will inherit the condition.
Keratosis palmoplantaris papulosa shows “age dependent penetrance” and possibly “variable penetrance” as well. Age dependant penetrance means that the older the person is, the more likely they are to develop symptoms if they have inherited the disease causing gene mutation.
Variable penetrance means that not everyone who inherits the gene mutation that causes keratosis palmoplantaris papulosa develops the signs and symptoms of the condition. However this person would still be at risk of passing the disease-causing mutation to their offspring.
In general, there has been some reported success using keratolytics such as corticosteroids, urea, salicylic acid, lactic acid, or Vitamin A. Systemic therapy using vitamin D analogues, aromatic retinoids, and 5-fluorouracil has also been used. However, individuals with successful resolution of lesions often relapse unless they are maintained on chronic low-dose therapy. These topical and systemic treatments carry a variety of side effects.
Surgery (including excision and skin grafting) for punctate keratodermas has been used on lesions resistant to medical treatment, but healing after surgical treatment can be difficult. CO2 laser ablation has also been attempted and reportedly produces good results for limited areas of hyperkeratosis of the palms.
Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.
The following online resources can help you find a genetics professional in your community:
- The National Society for Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.
- Martinez-Mir A et al. Identification of a locus for type I punctuate palmoplantar keratoderma on chromosome 15q22-q24. J Med Genet. 2003;
- Oztas P et al.,. Punctate palmoplantar keratoderma (Brauer-Buschke-Fisher Syndrome). Am J Clin Dermatol. 2007;
- Asadi AK. Type I hereditary punctuate keratoderma. Dermatology Online Journal. 2003;
- Erkek E et al.,. Type I Hereditary punctuate keratoderma associated with widespread lentigo simplex and successfully treated with low-dose oral acitretin. Arch Dermatology. 2006 Aug;
- KERATODERMA, PALMOPLANTAR, PUNCTATE TYPE I; PPKP1. OMIM. November, 2014; http://omim.org/entry/148600. Accessed 1/1/2016.
- Rapprich S, Hagedorn M. Surgical treatment of severe palmoplantar keratoderma. J Dtsch Dermatol Ges. March 2011; 9(3):252-255.
- Keratoderma, palmoplantar, punctuate type I. Online Mendelian Inheritance in Man. November, 2014; http://omim.org/entry/148600. Accessed 1/1/2016.
- Giehl KA, et al. Nonsense Mutations in AAGAB Cause Punctate Palmoplantar Keratoderma Type Buschke-Fischer-Brauer. Am J Hum Genet. October 5, 2012; 91(4):754-759.
- What are the different ways in which a genetic condition can be inherited?. Genetics Home Reference Web site. January 25, 2016; http://ghr.nlm.nih.gov/handbook/inheritance/inheritancepatterns.
- Kingsbery MY. Keratosis Palmaris et Plantaris. Medscape Reference. July 23 2014; http://emedicine.medscape.com/article/1108406-overview#a1. Accessed 12/30/2015.
- O'connor EA, Dzwierzynski WW. Palmoplantar keratoderma: treatment with CO2 laser case report and review of the literature. Ann Plast Surg. October 2011; 67(4):439-441.
- Palmoplantar keratoderma. DermNet NZ. 2015; http://www.dermnetnz.org/scaly/palmoplantar-keratoderma.html. Accessed 1/1/2016.
- Punctate-type palmoplantar keratoderma. DermNet NZ. September, 2015; http://www.dermnetnz.org/scaly/punctate-keratoderma.html. Accessed 1/1/2016.
- Patel S, Zirwas M, English JC 3rd. Acquired palmoplantar keratoderma. Am J Clin Dermatol. 2007; 8(1):1-11.