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Diseases

Genetic and Rare Diseases Information Center (GARD)

Familial partial lipodystrophy type 2


Other Names for this Disease
  • FPLD2
  • Lipodystrophy, familial partial, Dunnigan type
  • Lipodystrophy, familial, of limbs and lower trunk
  • Lipodystrophy, reverse partial
  • Lipoatrophic diabetes
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might familial partial lipodystrophy be treated?

Individuals with familial partial lipodystrophy type 2 may require the coordinated efforts of a team of specialists, including a primary care provider, cardiologist, endocrinologist, nutritionist, plastic surgeon, and psychiatrist/psychologist.[1] Dietary modifications and daily physical activity can help improve the metabolic complications of lipodystrophy. Insulin sensitizers (such as metformin) and lipid-lowering drugs (statins, fibrates) may also be helpful. Due to the risk of cardiac complications, individuals with familial partial lipodystrophy type 2 should have regular cardiac check-ups. Metreleptin has shown some promise as a treatment for this condition, however, it is not widely approved for treatment at this time.[1][2] The characteristic fat distribution seen in individuals with familial partial lipodystrophy type 2 cannot be reversed. For some individuals, cosmetic surgery may be beneficial in improving appearance and for management of metabolic complications. Liposuction may also be used to remove unwanted deposits of fat. Because familial partial lipodystrophy type 2 can cause anxiety and stress, psychological support is also an important part of treatment.[1]  
Last updated: 7/3/2016

References
  1. Garg A. Familial Partial Lipodystrophy. National Organization for Rare Disorders (NORD). 2015; http://rarediseases.org/rare-diseases/familial-partial-lipodystrophy/.
  2. Vigouroux C. Familial partial lipodystrophy, Dunnigan type. Orphanet. February 2015; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=2348.


Management Guidelines

  • The NORD Physician Guide  for Familial partial lipodystrophy type 2 was developed as a free service of the National Organization for Rare Disorders (NORD) and it's medical advisors.  The guides provide a resource for clinicians about specific rare disorders to facilitate diagnosis and treatment of their patients with this condition. 

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Familial partial lipodystrophy type 2. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • FPLD2
  • Lipodystrophy, familial partial, Dunnigan type
  • Lipodystrophy, familial, of limbs and lower trunk
  • Lipodystrophy, reverse partial
  • Lipoatrophic diabetes
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.