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Diseases

Genetic and Rare Diseases Information Center (GARD)

Diffuse Large B-Cell Lymphoma


Other Names for this Disease
  • DLBCL
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Overview

Diffuse large B-cell lymphoma (DLBCL), a form of non-Hodgkin lymphoma, is the most common blood cancer. Lymphomas occur when cells of the immune system, known as B lymphocytes, grow and multiply uncontrollably. DLBCL occurs mostly in adults and is an aggressive (fast-growing) lymphoma. It can arise in the lymph nodes or outside of the lymphatic system in the gastrointestinal tract, testes, thyroid, skin, breast, bone, or brain.[1] Often, the first sign of DLBCL is a painless rapid swelling in the neck, armpit, abdomen, or groin which is caused by enlarged lymph nodes. For some patients, the swelling may be painful. Other symptoms include night sweats, unexplained fevers, and weight loss.[1][2] The prognosis and treatment may differ depending on the location of the tumor and the subtype of lymphoma.[1][3] However, a combination of chemotherapy and the monoclonal antibody rituximab (Rituxan) (R-CHOP) is a widely used treatment for patients with advanced DLBCL.[1][2][3]. A stem cell transplant may be indicated for DLBCL patients whose cancer has returned or relapsed. [1]
Last updated: 6/28/2016

References

  1. Diffuse Large B-Cell Lymphoma. Lymphoma Research Foundation. http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6300153. Accessed 6/28/2016.
  2. Freedman, Arnold and Friedberg, Jonathan. Patient information: Diffuse large B cell lymphoma in adults (Beyond the Basics). UpToDate. June 30, 2016; http://www.uptodate.com/contents/diffuse-large-b-cell-lymphoma-in-adults-beyond-the-basics. Accessed 6/28/2016.
  3. Ghandi, Shipra. Diffuse Large Cell Lymphoma. Medscape. Feb.7, 2016; http://emedicine.medscape.com/article/202969-overview. Accessed 6/28/2016.
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In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
Other Names for this Disease
  • DLBCL
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.