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Diseases

Genetic and Rare Diseases Information Center (GARD)

Laryngeal cleft


Other Names for this Disease
  • Posterior laryngeal cleft (PLC)
  • Type 1A (minor laryngeal cleft)
  • Anterior submucous laryngeal cleft (subtype)
  • Congenital laryngeal clefts (subtype)
  • Cleft, larynx posterior
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Overview

laryngeal cleft is a rare abnormality of the separation between the larynx, or voice box, and the esophagus.[1][2] Normally, when the larynx develops, it is completely separate from the esophagus so swallowed foods go directly into the stomach. When a laryngeal cleft occurs, there is an opening between the larynx and the esophagus so food and liquid can pass through the larynx into the lungs.[1] There are several different types of laryngeal clefts (Types I through IV), classified based on the extent of the clefting.[3][4]
Last updated: 9/1/2011

References

  1. Laryngeal Cleft. Children's Hospital Boston. http://www.childrenshospital.org/az/Site1137/mainpageS1137P0.html. Accessed 8/30/2011.
  2. Pezzettigotta SM, Leboulanger N, Roger G, Denoyelle F, Garabedian EN. Laryngeal Cleft. Otolaryngol Clin North Am. 2008; 41:913-933. http://www.ncbi.nlm.nih.gov/pubmed/18775342. Accessed 8/30/2011.
  3. Tewfik TL, Karsan N, Laberge JM. Congenital Malformations of the Esophagus. eMedicine. 2010; http://emedicine.medscape.com/article/837879-overview. Accessed 8/30/2011.
  4. Rahbar R, Rouillon I, Roger G, Lin A, Nuss RC, Denoyelle F, McGill TJ, Healy GB, Garabedian EN. The Presentation and Management of Laryngeal Cleft. Archives of Ololaryngology-Head & Neck Surgery. 2006; 132:1335-1341. http://archotol.ama-assn.org/cgi/content/full/132/12/1335. Accessed 8/30/2011.
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In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Laryngeal cleft. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • Posterior laryngeal cleft (PLC)
  • Type 1A (minor laryngeal cleft)
  • Anterior submucous laryngeal cleft (subtype)
  • Congenital laryngeal clefts (subtype)
  • Cleft, larynx posterior
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.