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Diseases

Genetic and Rare Diseases Information Center (GARD)

Lewy body dementia

*

* Not a rare disease

Other Names for this Disease
  • Lewy body disease
  • DLB
  • Diffuse Lewy body disease
  • Autosomal dominant diffuse Lewy body disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Lewy body dementia is one of the most common forms of progressive dementia. People affected by this condition may experience a variety of symptoms such as changes in alertness and attention; hallucinations; problems with movement and posture; muscle stiffness; confusion; and/or memory loss. Although the exact cause of Lewy body dementia is poorly understood, symptoms are thought to result when clumps of a protein called alpha-synuclein ("Lewy bodies") accumulate in the brain. Lewy body dementia usually occurs sporadically in people with no family history of the condition. Rarely, more than one family member may be affected. There is currently no cure for Lewy body dementia; however, medications may be available to help manage the associated symptoms.[1][2][3]
Last updated: 11/5/2015

References

  1. NINDS Dementia With Lewy Bodies Information Page. National Institute of Neurological Disorders and Stroke (NINDS). November 2015; http://www.ninds.nih.gov/disorders/dementiawithlewybodies/dementiawithlewybodies.htm.
  2. Howard A Crystal, MD. Dementia With Lewy Bodies. Medscape Reference. April 2014; http://emedicine.medscape.com/article/1135041-overview#a4.
  3. Lewy Body Disease. MedlinePlus. October 2015; https://www.nlm.nih.gov/medlineplus/lewybodydisease.html.
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Basic Information

  • Mayo Clinic has an information page on Lewy body dementia.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
  • The National Institute on Aging (NIA) leads a national program of research on the biomedical, social, and behavioral aspects of the aging process; the prevention of age-related diseases and disabilities; and the promotion of a better quality of life for all older Americans. Click on the link to view information on this topic. 

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Lewy body dementia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Lewy body disease
  • DLB
  • Diffuse Lewy body disease
  • Autosomal dominant diffuse Lewy body disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.