Twin to twin transfusion syndrome
Other Names for this Disease
- Twin-to-twin transfusion syndrome
- Fetofetal transfusion syndrome
- Fetal transfusion syndrome
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 TTTS is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same "egg" sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). TTTS usually develops between 15 and 26 weeks of pregnancy. The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. Treatment may require repeated amniocentesis during pregnancy. Fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. After birth, treatment depends on the infant's specific symptoms. The donor twin may need a blood transfusion to treat anemia. The recipient twin may need to have the volume of body fluid reduced. This may involve an exchange transfusion. Medications may be given to treat heart failure in the recipient twin.Twin to twin transfusion syndrome (TTTS) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the “donor twin”) to the other (the “recipient twin”) while in the womb.
Last updated: 7/21/2016
- Twin-to-Twin Transfusion Syndrome. MedlinePlus. 9/26/2015; http://www.nlm.nih.gov/medlineplus/ency/article/001595.htm.
- Terence Zach. Twin-to-Twin Transfusion Syndrome. Medscape. Dec 30, 2015; http://emedicine.medscape.com/article/271752-overview.
- Twin to twin transfusion syndrome. Orphanet. February 2012; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=95431.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Twin to Twin Transfusion Syndrome Foundation has an information page that lists their most commonly asked questions regarding TTTS. Click on the link above to view this information page.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Twin to twin transfusion syndrome. Click on the link to view a sample search on this topic.